| Effects |
(1) BA clearly showed a pattern of dose-dependent accelerated fibrillation,ThT fluorescence analysis showed the optimum concentration of BA (0.05 μM) to inhibit tau protein aggregation;(2) Opposite of the positive U-G, the negative C-G, C-G-BA, and U-G-BA are demonstrated to delay or inhibit the fibrillation process in a dose-dependent manner. The fibrillation process was effectively inhibited with GNP-BA. (3) it has been found that clusterin, an extracellular chaperone, prevents the formation of tau fibrils by stabilizing tau monomers and interacting with their high-molecular-weight oligomers. This chaperone function of GNP-BA thereby increases the hydrophobicity of their surface |
