| IPAD-DB ID |
N00232 |
| Name |
hybrid peptide HNSS with nanoparticles (FGL-NP(Cit) /HNSS) |
| Category |
Nano-inhibitors |
| EC50 |
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| IC50 |
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| Inhibition |
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| Toxicity |
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| ROS(reactive oxygen species) |
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| Metal Chelating |
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| BBB(blood-brain barrier) |
PASS |
| Target Protein |
Tau protein |
| Effects |
(1) FGL-NP(Cit) /HNSS effectively rescued mitochondria dysfunction via the PGC-1α and STAT3 pathways, inhibited Aβ deposition and tau hyperphosphorylation, and ameliorated memory defects and cholinergic neuronal damage in 3xTg-AD mice. (2) The work provides a potential platform for targeted cationic peptide delivery, harboring utility for peptide therapy in other neurodegenerative diseases. |
| Research Models |
ICR mice ,nude mice,nude mice |
| Main Source |
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| Ref. Link |
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