Detailed Information for N00236
IPAD-DB ID N00236
Name NGF-SPIO-Au NPs
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein β3-tubulin
Effects (1) DMF stimulation of SPIO-Au NPs significantly upregulated β3-tubulin expression compared to NPs alone and SMF + NPs (P < 0.01 and P < 0.001, respectively) (2) SMF and DMF stimulation of NGF-SPIO-Au NPs significantly upregulated β3-tubulin expression compared to NGF-SPIO-Au NPs alone (P < 0.01 and P < 0.05, respectively) while there was no significant upregulation of β3-tubulin expression between SMF and DMF stimulations
Research Models PC-12 cells (from rat pheochromocytoma)  
Main Source
Ref. Link