Detailed Information for N00267
IPAD-DB ID N00267
Name NP(α-M)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein Aβ
Effects Elevate LDLR expression, and enhance Aβ uptake and degradation in microglia and liver cells; increase brain clearance of 125I-Aβ in an LDLR-dependent manner; led to decrease in amyloid deposition, attenuation of neuroinflammatory responses, amelioration of neurologic changes and rescue of memory deficits in AD model mice
Research Models BV-2 cells; SAMP8 and APP/PS1 mice
Main Source
Ref. Link