Detailed Information for N00269
IPAD-DB ID N00269
Name P80-Que@Se nanocomposites
Category Nano-inhibitors
EC50 -
IC50 -
Inhibition -
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein Aβ1-42
Effects (1) Nanocomposite carriers greatly increased the water solubility and bioavailability of Que; (2) P80-Que@Se nanocomposites effectively inhibited Aβ1–42 monomers aggregation; (3) P80-Que@Se nanocomposites exerted excellent antioxidant activity; (4) when H2O2 (1000 μM) was mixed with P80-Que@Se NCs (25 μM) , cell viability increased from 44 to 72.6%; (5) inhibited DPPH radical scavenging IC50 value was 44 μM;
Research Models PC12 cells
Main Source
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