(1) The PLGA@QT NPs effectively inhibited Zn2+-induced Aβ fibrils formation and toxicity; (2) That injection of PLGA@QT NPs into AD mice ameliorated cognition and memory impairments; (3) inhibited Aβ42 fibrils formation; (4) PLGA@QT NPs effectively decreased the β-sheet content corresponding to Aβ42 aggregates;
Research Models
SH-SY5Y cells, female BALB/c nude mice and APP/PS1 transgenic mice
