Detailed Information for E00149
IPAD-DB ID E00149
Name Betula utilis extract
Category Natural extracts
EC50
IC50
Inhibition
Toxicity BUE attenuates β-amyloid proteotoxicity and α-synuclein neurotoxicity in C. elegans
ROS(reactive oxygen species) (-)22.47%
Metal Chelating
BBB(blood-brain barrier)
Target Protein α-synuclein
Effects (1) BUE (50 μg/ml) extended the mean lifespan of C. elegans by 35.99% and increased its survival under stress conditions; (2) BUE attenuates the Aβ induced paralysis and reduces αS aggregation in transgenic strains; (3) BUE improved stress resistance in C. elegans; (4)BUE enhanced Chemotaxis index of worms; (5)The BUE treatment reduces lipofuscin in C. elegans;
Research Models Caenorhabditis elegans strains
Main Source Betula utilis 
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