BUE attenuates β-amyloid proteotoxicity and α-synuclein neurotoxicity in C. elegans
ROS(reactive oxygen species)
(-)22.47%
Metal Chelating
BBB(blood-brain barrier)
Target Protein
α-synuclein
Effects
(1) BUE (50 μg/ml) extended the mean lifespan of C. elegans by 35.99% and increased its survival under stress conditions; (2) BUE attenuates the Aβ induced paralysis and reduces αS aggregation in transgenic strains; (3) BUE improved stress resistance in C. elegans; (4)BUE enhanced Chemotaxis index of worms; (5)The BUE treatment reduces lipofuscin in C. elegans;