Detailed Information for E00158
IPAD-DB ID E00158
Name Callyspongia samarensis extracts
Category Natural extracts
EC50
IC50 14.47 μg/mL (AMPK activation)
Inhibition 99.82μg/mL (β-secretase 1）
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein Aβ-secretase 1
Effects (1) Acute oral toxicity test of MCS extract revealed that it is nontoxic, with an LD50 of>2000 mg/kg; (2) the compound 15 present in the MCS extract was able to cross the BBB;
Research Models Sprague-Dawley rats
Main Source
Ref. Link