Conjunctive treatment of GBE and Al for 6 weeks decreased the ROS levels by 55.94% and 3.84% in hippocampal and cortical regions of brain as compared with Al intoxicated rats
Metal Chelating
BBB(blood-brain barrier)
Target Protein
Aβ
Effects
(1) The possible effects of Ginkgo biloba (GBE) against aggregation of the Aβ through activation of heat shock proteins (HSPs) in the Aluminium (Al) induced AD based model；(2) GBE administration resulted in decrease in Aβ aggregation, ubiquitin deposition, accompanying a significant decline in APP & Tau protein hyperphosphorylation which can be attributed to activation of Heat shock factor (HSF-1) and upregulation in the protein expression of HSPs；(3) conjunctive treatment of GBE and Al for 6 weeks increased the nor-epinephrine levels by 66.38% and 10.45% in hippocampal and cortical regions of brain as compared to Al intoxicated rats; (4) conjunctive treatment of GBE and Al for 6 weeks significantly (p ≤ 0.05) decreased the AChE enzyme activity by 20.49% and 10.80% in hippocampal and cortical regions of brain as compared to Al intoxicated rats;
