Detailed Information for E00209
IPAD-DB ID E00209
Name Grape seed extract (GSE)
Category Natural extracts
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein
Effects (1) Amyloid plaques and microgliosis in the brain of Alzheimer’s mice fed with GSE were also reduced by 49% and 70%, respectively; (2) Curcumin also significantly reduced brain Aβ burden and microglia activation; (3) GSE Reduces Brain and Serum Aβ Levels and Prevents Aβ Deposition in APPSwe/PS1dE9 Transgenic Mice; (3) polyphenol-rich GSE prevents the Aβ deposition and attenuates the inflammation in the brain of a transgenic mouse model; (4) reduced 33% in the brain; reduced 44%in the serum;
Research Models APPSwe/PS1dE9 transgenic mice, astrocyte, microglia
Main Source
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