(1) Amyloid plaques and microgliosis in the brain of Alzheimer’s mice fed with GSE were also reduced by 49% and 70%, respectively; (2) Curcumin also significantly reduced brain Aβ burden and microglia activation; (3) GSE Reduces Brain and Serum Aβ Levels and Prevents Aβ Deposition in APPSwe/PS1dE9 Transgenic Mice; (3) polyphenol-rich GSE prevents the Aβ deposition and attenuates the inflammation in the brain of a transgenic mouse model; (4) reduced 33% in the brain; reduced 44%in the serum;