MN was a highly effective inhibitor of Aβ-induced toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein
Aβ42
Effects
(1) MN was able to inhibit protofibril formation, pre-protofibrillar oligomerization, and initial coil → α-helix/β-sheet secondary structure transitions; (2) MN inhibited β-sheet formation by both Aβ40 and Aβ42 in a concentration-dependent manner; (3) The effects of MN on Aβ42 assembly were similar in that fibril number and length were reduced greatly and the frequency of amorphous aggregates increased; (4) MN can almost completely inhibit Aβ oligomerization at compound:peptide ratios of ∼5:2 or lower; (5) attenuated AD-type cognitive deterioration and reduced high molecular weight soluble oligomeric Aβ in the brains of Tg2576 mice;
