| IPAD-DB ID |
E00225 |
| Name |
N-butanol extract of Hedyotis diffusa |
| Category |
Natural extracts |
| EC50 |
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| IC50 |
|
| Inhibition |
The number of Aβ deposits was significantly reduced by 47.5 % in CL2006 worms treated with 1.0 mg/mL HDB; |
| Toxicity |
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| ROS(reactive oxygen species) |
Feeding HDB (1.0 mg/mL) reduced the ROS level by 50.8 % (p< .001) in CL4176 compared to control nematodes |
| Metal Chelating |
Al |
| BBB(blood-brain barrier) |
|
| Target Protein |
Aβ |
| Effects |
(1) HDB improved lifespan, locomotion, and stress resistance; (2) HDB decreased paralysis, the accumulation of ROS, and AChE activity; (3) HDB suppressed neuronal Aβ-expression-induced defects in chemotaxis behavior and increased SOD activity; (4) HDB also downregulated the Aβ mRNA level and decreased the number of Aβ deposits; (5) HDB increased the expression levels of sod-3, daf-16, hsf-1, and hsp-16.2 gene and upregulated hsp-16.2::GFP and gst-4::GFP expression; (6) HDB may protect against Aβ-induced toxicity in C. elegans via the insulin/insulin-like growth factor-1 (IGF-1) signaling pathway; (7) HDB-treated group were 38.3 % lower than those in the control group (p< 0.01); |
| Research Models |
Caenorhabditis elegans CL4176, CL2006, and CL2355 strains |
| Main Source |
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| Ref. Link |
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