OPP significantly reduces the cytotoxicity of aggregating neuropeptides
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein
Aβ1-42
Effects
(1) OPP inhibits stacking of β-pleated sheets; (2) OPP inhibits the aggregation of Aβ into oligomers; (3) OPP inhibits fibrillar growth and coalescence; (2)In the transgenic yeast assay, the presence of 10 μg/ml OPP rescues the growth of the β-amyloid-producing yeast from 20% (without OPP) to 40% (with OPP);
Research Models
Yeast cells
Main Source
An aqueous extract from the oil palm tree (Elaeis guineensis)
