Ki |
- |
EC50 |
- |
IC50 |
1.14 mg/mL (Aβ40), 1.66 mg/mL( Aβ42 ) |
Inhibition |
- |
Toxicity |
Greatly reduces Aβ-induced cytotoxicity |
ROS(reactive oxygen species) |
downregulates intracellular reactive oxygen species production |
Metal Chelating |
- |
BBB(blood-brain barrier) |
- |
Target Protein |
Aβ1-40 |
Effects |
(1) Ulvan effectively inhibits Aβ fibrillogenesis in a concentration-dependent manner and actively inhibits the formation of A11-reactive Aβ oligomers, (2)The circular dichroism spectrum reveals that ulvan blocks the conformational transition of Aβ40 from the initial random coil to a β-sheet structure, but it only delays the conformational transition of Aβ42, (3)protects PC12 cells from the damage caused by Aβ fibrillation, |
Research Models |
PC12 cells |
Main Source |
An acidic polysaccharide from green algae of the genus Ulva |
Ref. Link |
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